Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway.

@article{Yu2011NovelIE,
  title={Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway.},
  author={Zhiwei Yu and Binbin Cui and Yinghu Jin and Haipeng Chen and Xishan Wang},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={411 4},
  pages={751-6}
}
BACKGROUND Epidermal growth factor receptor (EGFR) is widely expressed in multiple solid tumors including colorectal cancer by promoting cancer cell growth and proliferation. Therefore, the inhibition of EGFR activity may establish a clinical strategy of cancer therapy. METHODS In this study, using human colon adenocarcinoma HT29 and SW480 cells as research models, we compared the efficacy of four EGFR inhibitors in of EGFR-mediated pathways, including the novel irreversible inhibitor 324674… CONTINUE READING