Novel iron complexes and chelators based on cis,cis-1,3,5-triaminocyclohexane: iron-mediated ligand oxidation and biochemical properties

@article{Park1998NovelIC,
  title={Novel iron complexes and chelators based on cis,cis-1,3,5-triaminocyclohexane: iron-mediated ligand oxidation and biochemical properties},
  author={G Barratt Park and Feng H Lu and Neng Ye and Martin W. Brechbiel and Suzy V. Torti and Frank M. Torti and Roy P. Planalp},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={1998},
  volume={3},
  pages={449-457}
}
 The interaction of Fe(II) and Fe(III) with the novel Fe(II) chelator N,N′N″-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane (referred to as tachpyr) gives rise to six-coordinate, low-spin, cationic complexes of Fe(II). Tachpyr also displays a cytotoxicity toward cultured bladder cancer cells that is believed to involve coordination of intracellular iron. The anaerobic reaction of tachpyr with Fe(II) salts affords the Fe(II)-tachpyr2+ complex, but in presence of oxygen, oxidative… CONTINUE READING
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