Novel interferon-beta-induced gene expression in peripheral blood cells.

  title={Novel interferon-beta-induced gene expression in peripheral blood cells.},
  author={Mysore R Sandhya Rani and Jennifer Shrock and Swathi Appachi and Richard A. Rudick and Bryan R. G. Williams and Richard M Ransohoff},
  journal={Journal of leukocyte biology},
  volume={82 5},
Type I IFNs are used for treating viral, neoplastic, and inflammatory disorders. The protein products encoded by IFN-stimulated genes (ISGs) likely mediate clinical effects of IFN in patients. Macroarray assays, used for studying ISG induction in IFN-treated patients, comprise genes identified predominantly through analysis of long-term cell lines. To discover genes induced selectively by IFN-beta in PBMC, we exposed whole blood to physiological concentrations of IFN-beta. PBMC were prepared… CONTINUE READING


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