Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S.

@article{Dahlbck2017NovelII,
  title={Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S.},
  author={Bj{\"o}rn Dahlb{\"a}ck},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2017},
  volume={15 7},
  pages={1241-1250}
}
Factor V (FV) is a regulator of both pro- and anticoagulant pathways. It circulates as a single-chain procofactor, which is activated by thrombin or FXa to FVa that serves as cofactor for FXa in prothrombin activation. The cofactor function of FVa is regulated by activated protein C (APC) and protein S. FV can also function as an anticoagulant APC cofactor… CONTINUE READING