Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.

@article{Li2014NovelII,
  title={Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.},
  author={Wei Li and Ashutosh Upadhyay and Fabio L. Fontes and E. Jeffrey North and Yuehong Wang and Debbie C Crans and Anna E. Grzegorzewicz and Victoria E Jones and Scott G Franzblau and Richard E. Lee and Dean C Crick and Mary Jackson},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 11},
  pages={6413-23}
}
MmpL3, a resistance-nodulation-division (RND) superfamily transporter, has been implicated in the formation of the outer membrane of Mycobacterium tuberculosis; specifically, MmpL3 is required for the export of mycolic acids in the form of trehalose monomycolates (TMM) to the periplasmic space or outer membrane of M. tuberculosis. Recently, seven series of inhibitors identified by whole-cell screening against M. tuberculosis, including the antituberculosis drug candidate SQ109, were shown to… CONTINUE READING
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