Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study.

@article{Escalante2006NovelII,
  title={Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study.},
  author={Teresa Escalante and John D Shannon and Ana Maria Moura-da-Silva and Jos{\'e} Mar{\'i}a Guti{\'e}rrez and Jay William Fox},
  journal={Archives of biochemistry and biophysics},
  year={2006},
  volume={455 2},
  pages={144-53}
}
The hemorrhagic activity characteristic of viperid snake envenomations is due to the action of venom metalloproteinases (SVMPs) on the capillary vessel basement membrane (BM). This study compared the action of two SVMPs on BM in vitro (degradation of Matrigel) and in vivo (immunohistochemical assessment of BM markers in mouse gastrocnemius muscle). SVMPs BaP1 (belonging to the P-I class) and jararhagin (of the P-III class) had a similar proteolytic activity on azocasein and degraded Matrigel… CONTINUE READING