Novel insights in the regulation and mechanism of androgen action on bone.

@article{Sinnesael2013NovelII,
  title={Novel insights in the regulation and mechanism of androgen action on bone.},
  author={Mieke Sinnesael and Frank Claessens and Steven Boonen and D Vanderschueren},
  journal={Current opinion in endocrinology, diabetes, and obesity},
  year={2013},
  volume={20 3},
  pages={240-4}
}
PURPOSE OF REVIEW This review provides an update on the associations of testosterone, estrogens, sex hormone binding globulin, GH-IGF-I, osteocalcin and mechanical loading with relevance to skeletal health. RECENT FINDINGS The simple concept of a dual model of action of androgens, i.e. either directly via the androgen receptor or indirectly by estrogens, is proving more complicated because of novel interactions of these hormones and their receptors with other hormonal as well as mechanical… CONTINUE READING
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