Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors.

@article{Jhan2015NovelIT,
  title={Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors.},
  author={Hua-Jing Jhan and Jun-Jen Liu and Y Chen and Der-zen Liu and M J Sheu and H Ho},
  journal={Nanomedicine},
  year={2015},
  volume={10 8},
  pages={1263-74}
}
AIM A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. MATERIALS & METHODS It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) to form thermosensitive injectable hydrogels. RESULTS The DH700KMF-15 hydrogel resulted in efficient growth… CONTINUE READING

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