Novel inhibitory actions on platelet thromboxane and inositolphosphate formation by xanthones and their glycosides.

@article{Teng1989NovelIA,
  title={Novel inhibitory actions on platelet thromboxane and inositolphosphate formation by xanthones and their glycosides.},
  author={C. M. Teng and C. N. Lin and F. N. Ko and Kan Leung Cheng and T. F. Huang},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 21},
  pages={3791-5}
}
Xanthones and their glycosides were tested for their antiplatelet activities in washed rabbit platelets. Tripteroside acetate and norathyriol acetate were the most potent inhibitors. Tripteroside acetate inhibited platelet aggregation and ATP release induced by ADP, arachidonic acid, platelet-activating factor (PAF), collagen, ionophore A23187 and thrombin. The IC50 values of tripteroside acetate toward arachidonic acid- (100 microM) and collagen- (10 micrograms/ml) induced platelet aggregation… CONTINUE READING