Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation.

@article{Ogasawara2015NovelIT,
  title={Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation.},
  author={Sari Ogasawara and Yuhei Kiyota and Yoshiro Chuman and Ayano Kowata and Fumihiko Yoshimura and Keiji Tanino and Rui Kamada and Kazuyasu Sakaguchi},
  journal={Bioorganic & medicinal chemistry},
  year={2015},
  volume={23 19},
  pages={
          6246-9
        }
}
Protein phosphatase magnesium-dependent 1δ (PPM1D, Wip1) is a p53 inducible serine/threonine phosphatase. PPM1D is a promising target protein in cancer therapy since overexpression, missense mutations, truncating mutations, and gene amplification of PPM1D are reported in many tumors, including breast cancer and neuroblastoma. Herein, we report that a specific inhibitor, SL-176 that can be readily synthesized in 10 steps, significantly inhibits proliferation of a breast cancer cell line… CONTINUE READING
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