Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum).

@article{Jones2000NovelIO,
  title={Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum).},
  author={Adrian L Jones and Derek Herbert and Andrew J. Rutter and Jane E. Dancer and John L Harwood},
  journal={The Biochemical journal},
  year={2000},
  volume={347 Pt 1},
  pages={205-9}
}
The type II fatty acid synthases (FASs) of higher plants (and Escherichia coli) contain three condensing enzymes called beta-ketoacyl-ACP synthases (KAS), where ACP is acyl-carrier-protein. We have used novel derivatives of the antibiotic thiolactomycin to inhibit these enzymes. Overall de novo fatty acid biosynthesis was measured using [1-(14)C]acetate substrate and chloroplast preparations from pea leaves, and [1-(14)C]laurate was used to distinguish between the effects of the inhibitors on… CONTINUE READING

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