Novel inhibitors of the Pseudomonas aeruginosa virulence factor LasB: a potential therapeutic approach for the attenuation of virulence mechanisms in pseudomonal infection.

@article{Cathcart2011NovelIO,
  title={Novel inhibitors of the Pseudomonas aeruginosa virulence factor LasB: a potential therapeutic approach for the attenuation of virulence mechanisms in pseudomonal infection.},
  author={George R A Cathcart and Derek J. Quinn and Brett Greer and Pat Harriott and John F Lynas and Brendan F. Gilmore and Brian Walker},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 6},
  pages={2670-8}
}
Pseudomonas elastase (LasB), a metalloprotease virulence factor, is known to play a pivotal role in pseudomonal infection. LasB is secreted at the site of infection, where it exerts a proteolytic action that spans from broad tissue destruction to subtle action on components of the host immune system. The former enhances invasiveness by liberating nutrients for continued growth, while the latter exerts an immunomodulatory effect, manipulating the normal immune response. In addition to the… CONTINUE READING

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