Novel inhibitors of nitric oxide synthase with antioxidant properties.

Abstract

We previously described a series of imidazole-based inhibitors substituted at N-1 with an arylethanone chain as interesting inhibitors of neuronal nitric oxide synthase (nNOS), endowed with good selectivity vs endothelial nitric oxide synthase (eNOS). As a follow up of these studies, several analogs characterized by the presence of substituted imidazoles or… (More)
DOI: 10.1016/j.ejmech.2012.01.002

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