Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.

@article{Seidel2014NovelIO,
  title={Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.},
  author={Carole Seidel and Michael Schnekenburger and Clemens Zwergel and François Gaascht and Antonello Mai and Mario A. Dicato and Gilbert Kirsch and Sergio Valente and Marc Diederich},
  journal={Bioorganic & medicinal chemistry letters},
  year={2014},
  volume={24 16},
  pages={3797-801}
}
Histone deacetylases (HDACs) are well-established, promising targets for anticancer therapy due to their critical role in cancer development. Accordingly, an increasing number of HDAC inhibitors displaying cytotoxic effects against cancer cells have been reported. Among them, a large panel of chemical structures was described including coumarin-containing… CONTINUE READING

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