Novel inhibitors of Rac1 in metastatic breast cancer.

  title={Novel inhibitors of Rac1 in metastatic breast cancer.},
  author={Eliud Hern{\'a}ndez and Alina De La Mota-Peynado and Suranganie F Dharmawardhane and Cornelis P. Vlaar},
  journal={Puerto Rico health sciences journal},
  volume={29 4},
OBJECTIVE Rho family GTPases are molecular switches that control signaling pathways regulating a myriad of cellular functions. Rac1, a Rho family member, plays a critical role in several aspects of tumorigenesis, cancer progression, invasion, and metastasis. Rac proteins are not mutated in most invasive human cancers but are found to be overactive or over-expressed. Since Rho GTPases are activated by guanine nucleotide exchange factors (GEFs), inhibition of the interaction of Rac with its GEFs… CONTINUE READING


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