Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors

  title={Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors},
  author={Sunil Kumar and Samir Mehndiratta and Kunal Nepali and Manish K. Gupta and Surrinder Koul and Parduman Raj Sharma and Ajit Kumar Saxena and Kanaya Lal Dhar},
  booktitle={Organic and medicinal chemistry letters},
BACKGROUND The combretastatins are a class of natural stilbenoids. These molecules generally share three common structural features: a trimethoxy "A"-ring, a "B"-ring containing substituent often at C3' and C4', and an ethene bridge between the two rings, which provides necessary structural rigidity. Members of the combretastatin family possess varying ability to cause vascular disruption in tumors. Combretastatin binds to the colchicine binding site of β-subunit of tubulin. Despite having a… CONTINUE READING


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