Novel indole S,O-bisdesmoside, calanthoside, the precursor glycoside of tryptanthrin, indirubin, and isatin, with increasing skin blood flow promoting effects, from two Calanthe species (Orchidaceae).

  title={Novel indole S,O-bisdesmoside, calanthoside, the precursor glycoside of tryptanthrin, indirubin, and isatin, with increasing skin blood flow promoting effects, from two Calanthe species (Orchidaceae).},
  author={Masayuki Yoshikawa and Toshiyuki Murakami and Akinobu Kishi and Tetsuo Sakurama and Hisashi Matsuda and Manabu Nomura and Michinori Kubo},
  journal={Chemical \& pharmaceutical bulletin},
  volume={46 5},
The methanolic extracts from Calanthe discolor LINDL. and C. liukiuensis SCHLTR. were found to exhibit hair restoring and skin blood flow promoting activities. Through bioassay-guided separation using the skin blood flow increasing effect, a novel indole S,O-bisdesmoside, calanthoside, was isolated together with three new components, glucoindican, calaliukiuenoside, and calaphenanthrenol, and known compounds such as tryptanthrin, indirubin, isatin, and indican. The structures of the new… Expand
Recent Developments in the Synthesis and Applications of Isatins
Isatin (1H-indole-2,3-dione, Figure 1) was first obtained by Erdman and Laurent in 1841 as a product from the oxidation of indigo by nitric and chromic acids.1 Since then, isatin and its derivativesExpand
Benzoxazinoid and indoxyl glycosides from Wrightia religiosa
Abstract A new class of secondary metabolites of the family Apocynaceae, benzoxazinoid, was reported for the first time from Wrightia religiosa. A new benzoxazinoid glycoside, (2S)-2-O-β- dExpand
Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides.
Three new flavonoid glycosides (cissosides I, II, and III) and a new benzofuran-type stilbene ( cissusin) were isolated from the methanolic extract of the aerial parts of Cissus sicyoides cultivated in Brazil and inhibited the release of beta-hexosaminidase. Expand
Genus: Calanthe to Cyrtosia
  • E. Teoh
  • Biology
  • Medicinal Orchids of Asia
  • 2015
This large chapter describe the herbal usage and pharmacology of 73 species in 12 genera (Calanthe, Callostylis, Cephalanthera, Cleisostoma, Coelogyne, Conchidium, Corymborkhis, Cremastra, Crepidium,Expand
Ethnobotany, phytochemistry, pharmacology, and conservation of the genus Calanthe R. Br. (Orchidaceae).
  • Consolata Nanjala, Jing Ren, +5 authors Guang-Wan Hu
  • Medicine
  • Journal of ethnopharmacology
  • 2021
This review provides comprehensive information on the herbal uses, chemical components, pharmacological activities, and conservation of Calanthe, which might be useful in the future development of potent herbal medicines and facilitate the enactment of better conservation strategies. Expand
Progress in the studies on tryptanthrin, an alkaloid of history
  • Y. Jahng
  • Biology, Medicine
  • Archives of pharmacal research
  • 2013
Recent studies on the natural sources, biological activities and mechanisms of their actions, synthesis, structure–activity relationship, and metabolism of tryptanthrin are covered. Expand
Isatin 1-morpholinomethyl, 1-hydroxymethyl, 1-methyl, and their halogenated derivatives, redox behaviour
Abstract Isatin methyl derivatives have several pharmacotherapeutic applications, such as antibacterial, antifungal, antiviral, anticonvulsants and anticancer activities. The electrochemicalExpand
Specialized plant metabolites from indolic and polyphenolic biosynthetic pathways in Wrightia religiosa (Teijsm. & Binn.) Benth. and Wrightia pubescens R. Br. (Apocynaceae)
Abstract Phytochemical investigation of different organs and of the latex of Wrightia religiosa (Teijsm. & Binn.) Benth. as well as of the stem bark of Wrightia pubescens R. Br. (Apocynaceae), bothExpand
Tryptanthrin from microwave-assisted reduction of isatin using solid-state-supported sodium borohydride: DFT calculations, molecular docking and evaluation of its analgesic and anti-inflammatory activity
Density Functional Theory (DFT) calculations at the B3LYP/6-311++G (2df, 2pd) level of theory showed that compared to ascorbic acid, tryptanthrin shows higher antioxidant activity which may be improved upon by functionalizing the aromatic core to enhance its solubility in polar solvents. Expand
Indole alkaloid glycosides from the aerial parts of Strobilanthes cusia.
N'-β-d-Glucopyranosylindirubin (5) showed weak antibacterial activity (MIC 62.5-125 μM) against Staphylococcus aureus. Expand