Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo.

@article{Delekta2014NovelIC,
  title={Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo.},
  author={Phillip Charles Delekta and Craig J. Dobry and Janice A Sindac and Scott J. Barraza and Pennelope K Blakely and Jianming Xiang and Paul D. Kirchhoff and Richard F. Keep and David N. Irani and Scott D Larsen and D J Miller},
  journal={Journal of virology},
  year={2014},
  volume={88 19},
  pages={
          11199-214
        }
}
Neurotropic alphaviruses, including western, eastern, and Venezuelan equine encephalitis viruses, cause serious and potentially fatal central nervous system infections in humans for which no currently approved therapies exist. We previously identified a series of thieno[3,2-b]pyrrole derivatives as novel inhibitors of neurotropic alphavirus replication, using a cell-based phenotypic assay (W. Peng et al., J. Infect. Dis. 199:950-957, 2009, doi:http://dx.doi.org/10.1086/597275), and subsequently… CONTINUE READING
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