Novel in vivo imaging shows up-regulation of death receptors by paclitaxel and correlates with enhanced antitumor effects of receptor agonist antibodies.

@article{Gong2006NovelIV,
  title={Novel in vivo imaging shows up-regulation of death receptors by paclitaxel and correlates with enhanced antitumor effects of receptor agonist antibodies.},
  author={Jing Gong and David J. Yang and Saady Kohanim and Robin R. Humphreys and Lyle D. Broemeling and Razelle Kurzrock},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 12},
  pages={
          2991-3000
        }
}
Susceptibility to apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is mediated through cognate death receptor signaling. We hypothesized that auto-amplification of this apparatus would enhance antitumor effects in vivo and could be optimized using the results obtained from novel imaging techniques. We therefore imaged mice bearing human colorectal cancer (Colo205) tumor xenografts with HGS-ETR1 and HGS-ETR2 agonist antibodies to TRAIL receptor-1 (TRAIL-R1) and TRAIL… CONTINUE READING

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