Novel in vitro model for studying ureteric stent‐induced cell injury

@article{Elwood2010NovelIV,
  title={Novel in vitro model for studying ureteric stent‐induced cell injury},
  author={Chelsea Elwood and Dirk Lange and Richard D. Nadeau and Shannon Seney and Kelly L. Summers and Ben H. Chew and John Denstedt and Peter A. Cadieux},
  journal={BJU International},
  year={2010},
  volume={105}
}
To develop a novel in vitro model for the study of bladder and kidney epithelial cell injury akin to stent movement, as ureteric stents are associated with urinary tract complications that can significantly add to patient morbidity. These sequelae may be linked to inflammation triggered by stent‐mediated mechanical injury to the urinary tract. 
View on Wiley
scielo.br
14 Citations
Background Citations
4
Results Citations
1

14 Citations

Citation Type

Citation Type

In vivo assessment of a novel biodegradable ureteral stent
TLDR
In vivo testing of a newly developed biodegradable ureteral stent produced with natural-based polymers suggests this device to feature homogeneous degradation, good urine drainage, and high biocompatibility.
In vivo evaluation of the third generation biodegradable stent: a novel approach to avoiding the forgotten stent syndrome.
Ureteral stent technology: Drug-eluting stents and stent coatings
Advances in ureteral stents
TLDR
New designs including stents based on guidewire technology, gels, and a combination of self-expanding wire stents with polymer films are reviewed, showing hope on the horizon that new stents will be able to effectively tackle problems that are often seen with ureteral stents.
The use of triclosan eluting stents effectively reduces ureteral stent symptoms: a prospective randomized trial
Study Type – Therapy (RCT)
Comparison of efficacy and bladder irritation symptoms among three different ureteral stents: A double-blind, prospective, randomized controlled trial
TLDR
The Polaris Ultra ureteral stent showed similar efficacy and favorable tolerability in regard to bladder irritation symptoms, stent-related pain and presence of gross hematuria compared with other stents.
Determination of urinary prostaglandin E2 as a potential biomarker of ureteral stent associated inflammation.
  • Zi-Ao Huang, K. Scotland, +5 authors D. Lange
  • Medicine, Biology
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2020
In vitro multicompartmental bladder model for assessing blockage of urinary catheters: effect of hydrogel coating on dynamics of Proteus mirabilis growth.
Encrustations on ureteral stents from patients without urinary tract infection reveal distinct urotypes and a low bacterial load
TLDR
This study provides novel insights into the bacterial burden in ureteral stent encrustations and the urinary tract microbiome, which may be different from long-term stenting.
Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury.
...
1
2
...

References

SHOWING 1-10 OF 37 REFERENCES
Urethral in situ biocompatibility of new drug‐eluting biodegradable stents: an experimental study in the rabbit
TLDR
To assess the effect of drug‐Eluting properties on the degradation process and the biocompatibility of biodegradable drug‐eluting urethral stents, a large number of patients with high‐risk of infection are fitted with drug-eluting stents.
The effects of double J stenting on unobstructed ureters. An experimental and clinical study.
TLDR
It is suggested that double J stents may compromise urinary drainage when ureteric obstruction is not present, urging caution in their use in the damaged, unobstructed upper urinary tract.
Symptom characteristics and the development of tolerance with time in patients with indwelling double‐pigtail ureteric stents
TLDR
To determine the symptoms of and factors predicting the tolerance to double‐pigtail ureteric stents, and the development of tolerance with time, a large number of patients with confirmed or suspected cases of central giant cell granuloma are surveyed.
Triclosan loaded ureteral stents decrease proteus mirabilis 296 infection in a rabbit urinary tract infection model.
Growth factors in bladder wound healing.
Use of triclosan-eluting ureteral stents in patients with long-term stents.
TLDR
Although triclosan-eluting stents did not show a clinical benefit in terms of urine and stent cultures or overall subject symptoms compared with controls, their use did result in decreased antibiotic usage and significantly fewer symptomatic infections.
Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair.
TLDR
The results raise the possibility that a novel paracrine growth loop is activated by chemical damage and regulates epithelial cell growth during tubular repair.
Early and Late Complications of Double Pigtail Ureteral Stent
TLDR
Ureteral stents have proven to be an invaluable tool for endourologists as longer indwelling times are associated with an increasing frequency of incrustation, infections, secondary stone formation and obstruction of the stented tract.
Nonstented versus routine stented ureteroscopic holmium laser lithotripsy: a prospective randomized trial
TLDR
Routine stenting after Ureteroscopic intracorporeal lithotripsy with the holmium laser is not necessary as long as the procedure is uncomplicated for distal or middle ureteral calculis less than 2 cm.
Characterization of urinary symptoms in patients with ureteral stents.
...
1
2
3
4
...