Novel immunogenic antigens increase classification accuracy in meningioma to 93.84%.

@article{Ludwig2011NovelIA,
  title={Novel immunogenic antigens increase classification accuracy in meningioma to 93.84%.},
  author={Nicole Ludwig and Andreas Keller and Sabrina Heisel and Petra Leidinger and Stefanie Rheinheimer and Claudia U Andres and Bernhard Stephan and Wolf-Ingo Steudel and Erich Donauer and Norbert M. Graf and Bernhard Burgeth and Joachim Weickert and Hans-Peter Lenhof and Eckart Meese},
  journal={International journal of cancer},
  year={2011},
  volume={128 6},
  pages={1493-501}
}
There is growing evidence that simultaneous analysis of multiple autoantibody reactions can be utilized for diagnosis of neoplasms. Using a set of 57 meningioma-associated antigens, we recently separated meningioma patients from individuals without known disease with an accuracy of 90.3%. Here, we ask whether a largely increased set of immunogenic antigens can further improve this discrimination. We used an array with 1,827 human recombinant clones and measured reactivity of serum… CONTINUE READING

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