Novel immune-modulator identified by a rapid, functional screen of the parapoxvirus ovis (Orf virus) genome

@inproceedings{Mcguire2011NovelII,
  title={Novel immune-modulator identified by a rapid, functional screen of the parapoxvirus ovis (Orf virus) genome},
  author={M J Mcguire and Stephen A. Johnston and Kathryn F Sykes},
  booktitle={Proteome Science},
  year={2011}
}
The success of new sequencing technologies and informatic methods for identifying genes has made establishing gene product function a critical rate limiting step in progressing the molecular sciences. We present a method to functionally mine genomes for useful activities in vivo, using an unusual property of a member of the poxvirus family to demonstrate this screening approach. The genome of Parapoxvirus ovis (Orf virus) was sequenced, annotated, and then used to PCR-amplify its open-reading… CONTINUE READING
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