Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses.

Abstract

Imino sugars, such as N-butyl-deoxynojirimycin and N-nonyl-deoxynojirimycin (NNDNJ), are glucose analogues that selectively inhibit cellular alpha-glucosidase I and II in the endoplasmic reticulum and exhibit antiviral activities against many types of enveloped viruses. Although these molecules have broad-spectrum antiviral activity, their development has… (More)
DOI: 10.1128/AAC.01457-08

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