Novel hybrid DHPM-fatty acids: synthesis and activity against glioma cell growth in vitro.

@article{Treptow2015NovelHD,
  title={Novel hybrid DHPM-fatty acids: synthesis and activity against glioma cell growth in vitro.},
  author={Tamara Germani Marinho Treptow and Fabr{\'i}cio Figueir{\'o} and Elisa Helena Farias Jandrey and Ana Maria Oliveira Battastini and Christianne Gazzana Salbego and Juliana Bender Hoppe and Priscila S Taborda and Sabrina B Rosa and Luciana Almeida Piovesan and Caroline Da R Montes D'Oca and Dennis Russowsky and Marcelo G Montes D'Oca},
  journal={European journal of medicinal chemistry},
  year={2015},
  volume={95},
  pages={552-62}
}
We described the first synthesis of fatty acid 3,4-dihydropyrimidinones (DHPM-fatty acids) using the Biginelli multicomponent reaction. Antiproliferative activity on two glioma cell lines (C6 rat and U-138-MG human) was also reported. The novel DHPM-fatty acids reduced glioma cell viability relative to temozolomide. Hybrid oxo-monastrol-palmitic acid was… CONTINUE READING