Novel human polyomaviruses—Re‐emergence of a well known virus family as possible human carcinogens

  title={Novel human polyomaviruses—Re‐emergence of a well known virus family as possible human carcinogens},
  author={Harald zur Hausen},
  journal={International Journal of Cancer},
  • H. zur Hausen
  • Published 2008
  • Biology, Medicine
  • International Journal of Cancer
Polyomaviruses belong to a family of DNA tumorviruses that frequently cause cancer upon inoculation into heterologous hosts. The rhesus monkey virus SV40 and mouse polyomavirus have been studied in particular detail. Two members of the polyomavirus family, BK and JC viruses, were identified as human pathogens more than 30 years ago. Both are oncogenic when inoculated into newborn rodents. Their possible role in human cancers has been intensively investigated; conclusive results are, however… 
Prevalence of polyomaviruses and links with human diseases
This review addresses the involvement of the nine human polyomaviruses and simian virus 40 in human diseases, with a particular focus on their prevalence and the humoral response directed against structural antigens in the general population and in subjects presenting specific diseases.
Emerging polyomaviruses in the human population.
The current status of the prevalence, age and gender distribution, co-infection with other viruses, and the tropism of the emergingpolyomaviruses KI, WU, Merkel cell, and lymphotropic polyomavirus in the human population is summarized.
Merkel Cell Polyomavirus and Two Novel Polyomaviruses Are Chronically Shed from Human Skin
An improved rolling circle amplification (RCA) technique to isolate circular DNA viral genomes from skin swab specimens provided the first full-length, apparently wild-type cloned genomes for this polyomavirus species, and revealed the existence of two previously unknown polyomvirus species that are named human polyomAVirus-6 (HPyV6) and HPyV7.
Human Polyomaviruses in Skin Diseases
The use of advanced high-throughput sequencing and improved rolling circle amplification techniques have identified the novel human polyomaviruses KI, WU, Merkel cellpolyomavirus, HPyV6,HPyV7, trichodysplasia spinulosa-associated polyomvirus, and HPyv9.
An update on viral association of human cancers
Modern laboratory techniques can be expected to facilitate the identification of new emerging viruses whose association with malignancies is suggested by epidemiologic and clinical data.
The role of polyomaviruses in human disease.
5 Merkel Cell Polyomavirus : A Causal Factor in Merkel Cell Carcinoma
Observations suggest that MCPyV can contribute to Merkel cell carcinoma pathogenesis and may therefore add a new virus to the list of human cancer viruses.
[Polyomavirus newly discovered].
Detection of polyomavirus major capsid antigen (VP-1) in human pilomatricomas.
The detection of viral major capsid protein VP-1 in human pilomatricomas could indicate either an eventual infection of the virus in already developed tumors or alternatively, a direct involvement of polyomavirus in the pathogenesis of some pilom atricomas.
Phylogenetics, evolution, and medical importance of polyomaviruses.


Identification of a Third Human Polyomavirus
The identification of a previously unknown polyomvirus provisionally named KI polyomavirus, which is phylogenetically related to other primatepolyomaviruses in the early region of the genome but has very little homology to known polyomVirus in the late region, illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types.
Polyomaviruses of Birds: Etiologic Agents of Inflammatory Diseases in a Tumor Virus Family
The available literature on polyomaviruses of birds is reviewed, focusing on the characterization of the known viruses and the diseases caused by them and on approaches to investigate the mechanisms for their pathogenicity.
Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections
The presence of multiple instances of the virus in two continents suggests that this virus is geographically widespread in the human population and raises the possibility that the WU virus may be a human pathogen.
Characterization of a new polyomavirus (Polyomavirus papionis-2) isolated from baboon kidney cell cultures
The results suggest that in baboons there are two antigenically distinct polyomaviruses which circulate independently, and it is proposed that the two baboon viruses, SA 12 and the new virus, should be namedPolyomavirus papionis-1 andPolyomvirus papio anubis-2 respectively.
A Novel Polyomavirus (Goose Hemorrhagic Polyomavirus) Is the Agent of Hemorrhagic Nephritis Enteritis of Geese
It is concluded that the causative agent of HNEG is closely related to but clearly distinct from otherpolyomaviruses; this newly identified virus is named Goose hemorrhagic polyomavirus.
Is there a role for SV40 in human cancer?
  • D. Poulin, J. Decaprio
  • Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
There is inadequate evidence to support widespread SV40 infection in the population, increased tumor incidence in those individuals who received contaminated vaccine, or a direct role for SV40 in human cancer.
B‐Lymphotropic papovavirus and possibility of infections in humans
Sera of high reactivity in immunofluorescence tests also neutralized viral infectivity, suggesting that an agent antigenetically closely related to AGM‐LPV also infects part of the human population.
Infections Causing Human Cancer
Infections Causing Human Cancer by Harald Zur Hausen provides an excellent overview of the role of chiefly viruses and the Helicobacter group of bacteria in the development of human cancers and discusses the current understanding of their link to cancers.
The Vacuolating Virus, S.V.40
  • B. H. Sweet, M. Hilleman
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1960
Summary The newly discovered vacuolating virus, S.V.40, appears to be a common and essentially ubiquitous contaminant of rhesus monkey kidney cell cultures and a likely common contaminant of