Novel human metapneumovirus with a 180-nucleotide duplication in the G gene.


AIM To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. MATERIALS & METHODS Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. RESULTS A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. CONCLUSION This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.

DOI: 10.2217/fmb-2016-0211

Cite this paper

@article{Piana2017NovelHM, title={Novel human metapneumovirus with a 180-nucleotide duplication in the G gene.}, author={Mar{\'i}a Pi{\~n}ana and Jorgina Vila and Laura Gimferrer and Mar{\'i}a Eugenia Valls and Cristina Llobell Andr{\'e}s and Mar{\'i}a Gema Codina and Javier Ram{\'o}n and Mar{\'i}a del Carmen Mart{\'i}n and Francisco Fuentes and Rosario Saiz and Pilar Alcubilla and Carlos Rodrigo and Tom{\'a}s Pumarola and Andr{\'e}s Ant{\'o}n}, journal={Future microbiology}, year={2017}, volume={12}, pages={565-571} }