Novel human metapneumovirus with a 180-nucleotide duplication in the G gene.

Abstract

AIM To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. MATERIALS & METHODS Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. RESULTS A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. CONCLUSION This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.

DOI: 10.2217/fmb-2016-0211

Cite this paper

@article{Piana2017NovelHM, title={Novel human metapneumovirus with a 180-nucleotide duplication in the G gene.}, author={Mar{\'i}a Pi{\~n}ana and Jorgina Vila and Laura Gimferrer and Mar{\'i}a Eugenia Valls and Cristina Llobell Andr{\'e}s and Mar{\'i}a Gema Codina and Javier Ram{\'o}n and Mar{\'i}a del Carmen Mart{\'i}n and Francisco Fuentes and Rosario Saiz and Pilar Alcubilla and Carlos Rodrigo and Tom{\'a}s Pumarola and Andr{\'e}s Ant{\'o}n}, journal={Future microbiology}, year={2017}, volume={12}, pages={565-571} }