Novel human bronchial epithelial cell lines for cystic fibrosis research.

Abstract

Immortalization of human bronchial epithelial (hBE) cells often entails loss of differentiation. Bmi-1 is a protooncogene that maintains stem cells, and its expression creates cell lines that recapitulate normal cell structure and function. We introduced Bmi-1 and the catalytic subunit of telomerase (hTERT) into three non-cystic fibrosis (CF) and three… (More)
DOI: 10.1152/ajplung.90314.2008

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