Novel human antibody therapeutics: The age of the Umabs

  title={Novel human antibody therapeutics: The age of the Umabs},
  author={Sigrid R. Ruuls and Jeroen J Lammerts van Bueren and Jan G. J. van de Winkel and Paul W H I Parren},
  booktitle={Biotechnology journal},
Monoclonal antibodies represent a major and increasingly important category of biotechnology products for the treatment of human diseases. The state-of-the-art of antibody technology has evolved to the point where therapeutic monoclonal antibodies, that are practically indistinguishable from antibodies induced in humans, are routinely generated. We depict how our science-based approach can be used to further improve the efficacy of antibody therapeutics, illustrated by the development of three… CONTINUE READING
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Antibody discovery:The use of transgenic mice to generate human monoclonal antibod- Biotechnology Journal Biotechnol

  • S. A. Kellermann, L. L. Green
  • J. 2008,
  • 2008
1 Excerpt

Complement-dependent tumor cell lysis triggered by combinations of EGF-R antibodies

  • M. Dechant, W. Weisner, S. Berger, M Peipp
  • Cancer Res
  • 2008
1 Excerpt

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