Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.

@article{Kumar1997NovelHO,
  title={Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.},
  author={S. Kiran Kumar and Peter C. McDonnell and Rebecca J. Gum and A T Hand and Jae Cheol Lee and Peter R. Young},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={235 3},
  pages={533-8}
}
A novel homologue of p38 MAP kinase, called SAPK4, has been cloned which shares 61% amino acid identity with p38 and is expressed predominantly in testes, pancreas and small intestine. We also cloned an alternative form of p38beta, termed p38beta2, which lacks the additional 8 amino acid insertion unique to p38beta. p38, p38beta, p38beta2, ERK6/p38gamma/SAPK3, and SAPK4 were characterized with respect to stimulus-dependent activation in transfected cells, substrate specificity, and sensitivity… CONTINUE READING
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