Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus.

@article{Tran2011NovelHH,
  title={Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus.},
  author={Bich Thi Ngoc Tran and Liming Chen and Yang Liu and Jinlu Wu and Adri{\'a}n Vel{\'a}zquez-Campoy and Jayaraman Sivaraman and Choy Leong Hew},
  journal={Journal of virology},
  year={2011},
  volume={85 17},
  pages={9159-66}
}
Singapore grouper iridovirus (SGIV), a major pathogen of concern for grouper aquaculture, has a double-stranded DNA (dsDNA) genome with 162 predicted open reading frames, for which a total of 62 SGIV proteins have been identified. One of these, ORF158L, bears no sequence homology to any other known protein. Knockdown of orf158L using antisense morpholino oligonucleotides resulted in a significant decrease in virus yield in grouper embryonic cells. ORF158L was observed in nuclei and virus… CONTINUE READING