Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR).

Abstract

The human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR) and its ligand vascular endothelial growth factor (VEGF) play an essential role in tumor angiogenesis and in haematological malignancies. To inhibit VEGF induced signalling, intrabodies derived from two scFv fragments recognizing the VEGF receptor were generated. When these intrabodies… (More)

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@article{Bldicke2005NovelHE, title={Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR).}, author={Thomas B{\"{o}ldicke and Holger Weber and Peter P. M{\"{u}ller and Bernhard Barleon and Mar{\'i}a {\'A}ngeles Bernal}, journal={Journal of immunological methods}, year={2005}, volume={300 1-2}, pages={146-59} }