Novel high-affinity PPARγ agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1

@article{Copland2006NovelHP,
  title={Novel high-affinity PPARγ agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1},
  author={John A. Copland and Laura A. Marlow and Shinichi Kurakata and Keishi Fujiwara and Alexander KC Wong and Pamela A Kreinest and Sandra F Williams and B Haugen and Joshua P. Klopper and Robert C. Smallridge},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={2304-2317}
}
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists demonstrate antitumor activity likely through transactivating genes that regulate cell proliferation, apoptosis, and differentiation. The PAX8/PPARγ fusion oncogene, which is common in human follicular thyroid carcinomas appears to act via dominant negative suppression of wild-type PPARγ, suggesting that it may be a tumor suppressor gene in thyroid cells. We have identified a novel high-affinity PPARγ agonist (RS5444) that is… CONTINUE READING
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