Novel hepatoselective insulin analog: studies with a covalently linked thyroxyl-insulin complex in humans.

@article{ShojaeeMoradie2000NovelHI,
  title={Novel hepatoselective insulin analog: studies with a covalently linked thyroxyl-insulin complex in humans.},
  author={Fariba Shojaee-Moradie and James K. Powrie and Erik Sundermann and M W Spring and Achim Sch{\"u}ttler and Peter S{\"o}nksen and Dietrich Brandenburg and R. H. Jones},
  journal={Diabetes care},
  year={2000},
  volume={23 8},
  pages={
          1124-9
        }
}
OBJECTIVE To test whether a thyroxyl-insulin analog with restricted access to receptor sites in peripheral tissues displays relative hepatoselectivity in humans. RESEARCH DESIGN AND METHODS Five normal human subjects received a subcutaneous bolus injection of either N(alphaBl) L-thyroxyl-insulin (Bl-T4-Ins) or NPH insulin in random order. Insulin kinetics, relative effects on hepatic glucose production, and peripheral glucose uptake were studied using euglycemic clamp and stable isotope [D-6… 

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