Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer.

@article{Weber1999NovelHA,
  title={Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer.},
  author={Thomas K. Weber and H. M. Chin and M. Rodriguez-Bigas and Bernadette T. Keitz and Ryan P. Gilligan and Lisa O’Malley and Edwin Urf and N. Diba and Joanna Pazik and Nicholas J. Petrelli},
  journal={JAMA},
  year={1999},
  volume={281 24},
  pages={
          2316-20
        }
}
  • Thomas K. Weber, H. M. Chin, +7 authors Nicholas J. Petrelli
  • Published in JAMA 1999
  • Medicine
  • CONTEXT Germline mutations of the DNA mismatch repair (MMR) genes hMLH1 and hMSH2 have been shown to cosegregate with the colorectal cancer phenotype in multiple hereditary nonpolyposis colorectal cancer (HNPCC) pedigrees. However, the frequency of these mutations among African American patients with colorectal cancer is unknown. OBJECTIVE To investigate the frequency of germline alterations of the DNA MMR genes hMLH1 and hMSH2 among African Americans affected by HNPCC and early-age onset… CONTINUE READING

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