Novel gyrA and parC point mutations in two strains of Acinetobacter baumannii resistant to ciprofloxacin.

@article{Hamouda2004NovelGA,
  title={Novel gyrA and parC point mutations in two strains of Acinetobacter baumannii resistant to ciprofloxacin.},
  author={Ahmed Mahmoud Ahmed Hamouda and Sebastian G. B. Amyes},
  journal={The Journal of antimicrobial chemotherapy},
  year={2004},
  volume={54 3},
  pages={
          695-6
        }
}
  • A. Hamouda, S. Amyes
  • Published 1 September 2004
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
non-nucleoside reverse transcriptase inhibitor resistance due to the low genetic barrier to resistance and relatively preserved fitness of non-nucleoside reverse transcriptase inhibitor-resistant virus. 9 While the relationship between adherence and resistance may be complex, we want to be completely clear that we are not suggesting that good adherence is bad. Even with early HAART, every 10% improvement in adherence was associated with a 20% decrease in the risk of progression to AIDS and… 
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Results Citations
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56 Citations

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Mechanisms of resistance to ciprofloxacin, ampicillin/sulbactam and imipenem in Acinetobacter baumannii clinical isolates in Taiwan.
Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection
TLDR
The genetic evolution of A. baumannii isolated from a patient with severe burns over the course of their stay in ICU is analysed to provide evidence for carbapenem resistance arising in vivo via non-synonymous substitutions during a single infection episode, demonstrating carbapanem resistance can emerge in genetic isolation in response to exposure to carbAPenems and other drugs.
Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection
TLDR
Structural modelling of AdeB and FtsI showed that these mutations affected their drug-binding sites and revealed mechanisms for meropenem resistance, suggesting exposure to one drug whose resistance is mediated by the efflux pump can induce collateral resistance to other drugs to which the bacterium has not yet been exposed.
Detection of highly ciprofloxacin resistance acinetobacter baumannii isolated from patients with burn wound infections in presence and absence of efflux pump inhibitor.
TLDR
It seems that mutation in GyrA is the main mechanism of resistant to ciprofloxacin among A. baumannii isolates from burn infections and presence of efflux pumps is just secondary target for cipronolone resistant among A-C.
Molecular Study of Quinolone Resistance Determining Regions of gyrA Gene and parC Genes in Clinical Isolates of Acintobacter baumannii Resistant to Fluoroquinolone
TLDR
Resistance to ciprofloxacin was common in clinical isolates of A. baumannii and the most frequent mutations were present in gyrA and parC, however, mutations in parC alone were not uncommon.
Evaluation of Resistance to Fluoroquinolones and Its Relationship whit parC Gene Mutation in Klebsiella pneumoniae Clinical Isolates
TLDR
Investigating the pattern of fluoroquinolone resistance and its relation with a mutation in the parC gene among clinical isolates of Klebsiella pneumoniae found it can be one of the major contributors to resistance to fluoroquolones and increased MDR bacteria and nosocomial infections.
In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid.
TLDR
In vitro stepwise combination of Gly-81-->Asp in GyrA and Ser-80-->Arg in ParC reproduced the original phenotype in E. coli KL16, suggesting a clonal relationship and acquisition of quinolone resistance by chromosomal mutation.
Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumannii
Correlation of Antimicrobial Resistance with β-Lactamases, the OmpA-Like Porin, and Efflux Pumps in Clinical Isolates of Acinetobacter baumannii Endemic to New York City
TLDR
Acinetobacter baumannii has become a well-equipped nosocomial pathogen; defining the relative contribution of these and other mechanisms of antimicrobial resistance will require further investigation.
Phenotypic Detection of Efflux Mechanism in Panaminoglycoside Resistant Acinetobacter baumannii from Egyptian Clinical Isolates
TLDR
The study suggests that the efflux mechanism is getting widespread in clinical settings to play an important role in aminoglycoside resistance and the application of strict infection control measures together with novel approaches to eradicate those efflux transporters should be applied in hospital settings.
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References

SHOWING 1-10 OF 16 REFERENCES
Drug resistance in patients experiencing early virological failure under a triple combination including indinavir
TLDR
Resistance to nucleoside analogues was more frequent than resistance to indinavir; treatment intensification in those patients without resistance, or a selective substitution of nucleosides in those with resistance limited to these compounds, might be justified.
Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii
TLDR
The results suggest that a gyrA mutation at Ser-83 is associated with quinolone resistance in A. baumannii.
Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii.
TLDR
The results suggest that ParC from A. baumannii is a secondary target for quinolones and that mutations at residues Ser80 and Glu84, when combined with mutations at Ser83 of GyrA, may render A.baumannies highly resistant to quInolones.
Virologic Rebound on HAART in the Context of Low Treatment Adherence Is Associated With a Low Prevalence of Antiretroviral Drug Resistance
TLDR
In viremic subjects, lower postdose NFV levels were associated with higher resistance, and in nonviremic groups, there were no differences between the groups in pharmacokinetics.
High levels of adherence do not prevent accumulation of HIV drug resistance mutations
TLDR
Increasing rates of viral suppression at high levels of adherence is balanced by increasing rates of drug resistance among viremic patients, which will not prevent population levels ofdrug resistance.
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli
TLDR
Nucleotide sequence analysis disclosed that all nine spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16 had a point mutation from aspartic acid to asparagine at amino acid 426 and that all four type 2 mutants had apoint mutation from lysine to glutamic acid at amino acids 447.
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
TLDR
A substantial proportion of homeless and marginally housed individuals had good adherence to PI therapy and a strong relationship was found between independent methods of measuring adherence and concurrent viral suppression.
Modeling the HIV protease inhibitor adherence-resistance curve by use of empirically derived estimates.
TLDR
This work statistically modeled the relationship between adherence and development of drug resistance, using empirically defined relationships of the rate of viral suppression and drug-resistance-mutation accumulation derived from patients receiving protease-inhibitor-based therapy.
A guide to sensitivity testing. Report of the Working Party on Antibiotic Sensitivity Testing of the British Society for Antimicrobial Chemotherapy.
  • D. Persing
  • Physics
    The Journal of antimicrobial chemotherapy
  • 1991
TLDR
The spectral picture uniformly changes the population index, although for those who have eyes telescopes Andromeda nebula would have seemed the sky was the size of a third of the Big dipper, although the galaxy in the constellation of the Dragon could be called a dwarf.
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli
TLDR
It is disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.
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