Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP-9 secretion.

  title={Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP-9 secretion.},
  author={Haisle Moon and Cl{\'e}ment V M Cremmel and Alina Kulpa and Nicolas A. F. Jaeger and Reinhild Kappelhoff and Christopher M. Overall and John Douglas Waterfield and Donald Maxwell Brunette},
  journal={Journal of biomedical materials research. Part A},
  volume={104 9},
Rough surface topographies on implants attract macrophages but the influence of topography on macrophage fusion to produce multinucleated giant cells (MGC) and foreign body giant cells (FBGC) is unclear. Two rough novel grooved substrata, G1 and G2, fabricated by anisotropic etching of Silicon <110> crystals without the use of photolithographic patterning, and a control smooth surface (Pol) were produced and replicated in epoxy. The surfaces were compared for their effects on RAW264.7… CONTINUE READING
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