Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability.

David Dangoor; Barbara Biondi; Marina Gobbo; Yelena Vachutinski; Mati Fridkin; Illana Gozes; Raniero Rocchi

Chemistry, Medicine
Published in
Journal of peptide science…
2008
DOI:10.1002/psc.932

Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability.

@article{Dangoor2008NovelGV,
  title={Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability.},
  author={David Dangoor and Barbara Biondi and Marina Gobbo and Yelena Vachutinski and Mati Fridkin and Illana Gozes and Raniero Rocchi},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2008},
  volume={14 3},
  pages={
          321-8
        }
}

David Dangoor, Barbara Biondi, +4 authors Raniero Rocchi

Vasoactive intestinal peptide (VIP) is a prominent neuropeptide, exhibiting a wide spectrum of biological activities in mammals. However, the clinical applications of VIP are mainly hampered because of its rapid degradation in vivo. Peptide glycosylation, a procedure frequently used to increase peptide resistance to proteolytic degradation and consequently increase peptide metabolic stability, has not been performed yet on VIP. The presence of three N-glycosylation sites on VIP receptor type 1… CONTINUE READING

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