Novel glucosensor for hypoglycemic detection localized to the portal vein.

  title={Novel glucosensor for hypoglycemic detection localized to the portal vein.},
  author={Andrea L. Hevener and Richard N Bergman and Casey M. Donovan},
  volume={46 9},
In this investigation, we sought to constrain the locus of essential portohepatic glucosensors and test the hypothesis that they reside strictly in the portal vein and not the liver. Male Wistar rats were chronically cannulated in the carotid artery (sampling), jugular vein (infusion), and portal vein, either adjacent to (POR[ADJ], 0.6 +/- 0.1 cm, n = 6) or upstream from (POR[UPS], 2.7 +/- 0.1 cm, n = 8) the liver. Animals were exposed to one of three protocols distinguished by the site of… CONTINUE READING


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