Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer.

Abstract

A novel germline transmission of the epidermal growth factor receptor (EGFR) mutation V843I in a family with multiple members with lung cancer is reported. The proband was a 70-year-old woman with multiple adenocarcinomas who exhibited secondary EGFR mutations, either L858R or L861Q, in the specimens of resected tumors, in addition to a germline EGFR V843I… (More)
DOI: 10.1016/j.athoracsur.2007.10.012

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@article{Ikeda2008NovelGM, title={Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer.}, author={Kouei Ikeda and Hiroaki Nomori and Takeshi Mori and J. M. Sasaki and Toshiaki Kobayashi}, journal={The Annals of thoracic surgery}, year={2008}, volume={85 4}, pages={1430-2} }