Novel genomic rearrangement that affects expression of the Streptococcus pyogenes streptolysin O (slo) gene.

A RecA-independent chromosomal rearrangement in the upstream region of the streptolysin O (slo) gene of Streptococcus pyogenes which affects slo expression was identified. PCR analysis was used to demonstrate that this kind of rearrangement was found in several strains of different lineages. Chromosomal loci involved in the recombination were found to be… CONTINUE READING