Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma

@article{Zimonjic2001NovelGI,
  title={Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma},
  author={D Zimonjic and Catherine L. Keck-Waggoner and N D Popescu},
  journal={Leukemia},
  year={2001},
  volume={15},
  pages={1582-1588}
}
In this study, CA46 and ST486, two Epstein–Barr (EBV) negative cell lines derived from sporadic BL, were analyzed by multicolor spectral karyotyping, G-banding, fluorescence in situ hybridization with single-copy gene probes, and comparative genomic hybridization (CGH). In addition to reciprocal t(8;14)(q24;q32) translocation involving c-myc and IgH loci, we identified a t(7;8;14)(q11.2;q24;q32) translocation in CA 46 cells and t(8;14;18)(q24;q32;q23) in ST486 cells. Both rearrangements were… CONTINUE READING

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Acquired, non-random chromosomal abnormlities associated with the development of acute promyelocitic leukemia in transgenic mice

  • DB Zimonjic, J Pollock, P Westerfield, NC Popescu, JT. Ley
  • Proc Natl Acad Sci USA
  • 2000

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