Novel genetic variants in microRNA genes and familial breast cancer

@article{Shen2009NovelGV,
  title={Novel genetic variants in microRNA genes and familial breast cancer},
  author={Jie Shen and Christine B. Ambrosone and Hua Zhao},
  journal={International Journal of Cancer},
  year={2009},
  volume={124}
}
MicroRNA (miRNA) plays an important role in tumorigenesis, but whether miRNA is a cancer predisposition factor or not is still unknown. Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. To test this hypothesis, we screened genetic variants in 17 selected miRNA genes, which are predicted to regulate key breast cancer genes, in 42… 

Novel genetic variants in miR-191 gene and familial ovarian cancer

Those certain genetic variants in miRNA genes can affect the expression of mature miRNAs and, consequently, might alter the regulation of TSGs or oncogenes and, thereby, cancer risk.

A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk

It is hypothesized that the G-variant of rs895819 might impair the maturation of the oncogenic miR-27a and thus, is associated with familial breast cancer risk.

Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations

Whether miRNA dysregulation is involved in the pathogenesis of BRCA-mutated BC is determined by an expression analysis of 14 human miRNAs previously shown to be related to BC diagnosis, prognosis, and drug resistance using tissues from 60 familial and/or early-onset patients whose peripheral blood samples had been screened for BRCM mutations through sequence analysis.

MicroRNA in breast cancer: The association with BRCA1/2.

The present review discusses the latest data from studies that focus on the complex network of miRNAs and BRCA1/2 related BCs, which might be important for improving the therapy within the patients with triple-negative BC and basal-like BC, and for understanding the formation of TNBC.

Genetic variants in microRNAs and breast cancer risk in African American and European American women

Data show, for the first time, that miRNA-related genetic variations may underlie the etiology of breast cancer in both populations of African and European ancestries.

MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression

The results indicate that miR-498 regulates BRCA1 expression in breast cancer and its overexpression could contribute to the pathogenesis of sporadic TNBC via B RCA1 downregulation.

BRCA 1 and MicroRNAs : Emerging Networks and Potential Therapeutic Targets

This review will describe recent progress in the understanding of the BRCA1 function through microRNAs and the role of micro RNAs in regulating BRCa1, with emphasis on the implication of these processes on the development and progression of cancer.

Two novel variants in the 3′UTR of the BRCA1 gene in familial breast and/or ovarian cancer

A weak genomic variability in the 3′UTR of the BRCA1 gene is revealed, leading to the classification of the novel variant c.*750A>G as probably neutral, the variants c.*1286C>A remaining unclassified.
...

References

SHOWING 1-10 OF 17 REFERENCES

MicroRNA genes are frequently located near mouse cancer susceptibility loci

A statistically significant association between the chromosomal location of miRNAs and those of mouse cancer susceptibility loci that influence the development of solid tumors is reported, which provides a catalog of miRNA genes in inbred strains that could represent genes involved in the development and penetrance ofSolid tumors.

MicroRNA signatures in human cancers

MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.

Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA.

This study reveals an additional structural requirement for pri-miRNA processing and emphasizes the importance of identifying new miRNA SNPs and their contributions to miRNA biogenesis and human genetic disease.

Human polymorphism at microRNAs and microRNA target sites

Although the majority of SNPs appear to be evolving under neutrality, interestingly, some of these SNPs are found at relatively high population frequencies even in experimentally verified targets, and a few variants are associated with atypically long-range haplotypes that may have been subject to recent positive selection.

Polymorphisms in human pre-miRNAs.

  • N. IwaiH. Naraba
  • Biology
    Biochemical and biophysical research communications
  • 2005

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.

A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele.

Ten genes for inherited breast cancer.

Polygenic susceptibility to breast cancer and implications for prevention

The results suggest that the construction and use of genetic-risk profiles may provide significant improvements in the efficacy of population-based programs of intervention for cancers and other diseases.

Sequence requirements for micro RNA processing and function in human cells.

The results suggest that miRNAs, and the closely similar small interfering RNAs, cannot totally discriminate between RNA targets differing by a single nucleotide.

Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.

Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer.