Novel genetic variants in microRNA genes and familial breast cancer

  title={Novel genetic variants in microRNA genes and familial breast cancer},
  author={Jie Shen and Christine B. Ambrosone and Hua Zhao},
  journal={International Journal of Cancer},
MicroRNA (miRNA) plays an important role in tumorigenesis, but whether miRNA is a cancer predisposition factor or not is still unknown. Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. To test this hypothesis, we screened genetic variants in 17 selected miRNA genes, which are predicted to regulate key breast cancer genes, in 42… 

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