Novel genetic basis of field-evolved resistance to Bt toxins in Plutella xylostella.

  title={Novel genetic basis of field-evolved resistance to Bt toxins in Plutella xylostella.},
  author={Simon W. Baxter and J-Z Zhao and Linda J. Gahan and Anthony M. Shelton and Bruce E Tabashnik and David G. Heckel},
  journal={Insect molecular biology},
  volume={14 3},
Insecticidal toxins from Bacillus thuringiensis (Bt) are widely used to control pest insects, but evolution of resistance threatens their continued efficacy. The most common type of Bt resistance ('Mode 1') is characterized by recessive inheritance, > 500-fold resistance to at least one Cry1A toxin, negligible cross-resistance to Cry1C, and reduced binding of Bt toxins to midgut membrane target sites. Mutations affecting a Cry1A-binding midgut cadherin protein are linked to laboratory-selected… CONTINUE READING

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