Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo.

@article{Sharma2000NovelGC,
  title={Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo.},
  author={Vijay Lakshami Sharma and Alexander Beatty and Shiaw P. Wey and Julie L Dahlheimer and Christina M. Pica and Carolyn L. Crankshaw and Laura Bass and Mark A Green and Michael J. Welch and David R. Piwnica-Worms},
  journal={Chemistry & biology},
  year={2000},
  volume={7 5},
  pages={335-43}
}
BACKGROUND Multidrug resistance (MDR) mediated by expression of MDR1 P-glycoprotein (Pgp) represents one of the best characterized barriers to chemotherapy in cancer patients. Positron emission tomography (PET) agents for analysis of Pgp-mediated drug transport activity in vivo would enable noninvasive assessment of chemotherapeutic regimens and MDR gene therapy. RESULTS Candidate Schiff-base phenolic gallium(III) complexes were synthesized from their heptadentate precursors and gallium(III… CONTINUE READING
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