Novel functions of proteins encoded by viral stress-inducible genes.

  title={Novel functions of proteins encoded by viral stress-inducible genes.},
  author={Saumendra N Sarkar and Ganes C Sen},
  journal={Pharmacology & therapeutics},
  volume={103 3},
The interferon (IFN) system is the first line of defense against viral infection in vertebrates. It is well known that IFN synthesis is induced by viral infection and secreted IFN act upon as yet uninfected neighboring cells to prepare them for combating oncoming virus infection. The products of IFN-stimulated genes (ISG), which number in hundreds, mediate this antiviral action of IFN. Recent evidence suggests that many of these genes are also induced directly by double-stranded RNA (dsRNA), a… CONTINUE READING


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