Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas.

@article{AitLounis2007NovelFO,
  title={Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas.},
  author={Aouatef Ait-Lounis and Dominique Baas and Emmanu{\`e}le Barras and Carine Benadiba and Anne Charollais and Rachel Nlend Nlend and Delphine Li{\`e}geois and Paolo Meda and B{\'e}n{\'e}dicte Durand and Walter Reith},
  journal={Diabetes},
  year={2007},
  volume={56 4},
  pages={950-9}
}
The transcription factor regulatory factor X (RFX)-3 regulates the expression of genes required for the growth and function of cilia. We show here that mouse RFX3 is expressed in developing and mature pancreatic endocrine cells during embryogenesis and in adults. RFX3 expression already is evident in early Ngn3-positive progenitors and is maintained in all major pancreatic endocrine cell lineages throughout their development. Primary cilia of hitherto unknown function present on these cells… CONTINUE READING
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