Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin.

@article{Awasthi2000NovelFO,
  title={Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin.},
  author={Sajeela Awasthi and Jiongjia Cheng and Sharad S Singhal and Mukesh Kumar Saini and U. R. Pandya and Sławomir Pikuła and Joanna Bandorowicz-Pikula and Shivendra V Singh and Piotr Zimniak and Yogesh C. Awasthi},
  journal={Biochemistry},
  year={2000},
  volume={39 31},
  pages={
          9327-34
        }
}
Active transport of conjugated and unconjugated electrophiles out of cells is essential for cellular homeostasis. We have previously identified in human tissues a transporter, DNP-SG [S-(2, 4-dinitrophenyl)glutathione] ATPase, capable of carrying out this function [Awasthi et al. (1998) Biochemistry 37, 5231-5238, 5239-5248]. We now report the cloning of DNP-SG ATPase. The sequence of the cDNA clone was identical to that of human RLIP76, a known Ral-binding protein. RLIP76 expressed in E. coli… CONTINUE READING

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