Novel frameshift mutation in the p16/INK4A tumor suppressor gene in canine breast cancer alters expression from the p16/INK4A/p14ARF locus.

@article{Kabir2013NovelFM,
  title={Novel frameshift mutation in the p16/INK4A tumor suppressor gene in canine breast cancer alters expression from the p16/INK4A/p14ARF locus.},
  author={Farruk Mohammad Lutful Kabir and Payal Agarwal and Patricia A Deinnocentes and Jishan Zaman and Allison E. Church Bird and Richard Curtis Bird},
  journal={Journal of cellular biochemistry},
  year={2013},
  volume={114 1},
  pages={56-66}
}
The INK4 family of cyclin-dependent kinase inhibitors (CKI) encode important cell cycle regulators that tightly control cell cycle during G1 to S phase. These related genes are considered tumor suppressors as loss of function contributes to the malignant phenotype. Expression of CKIs p16, p14ARF, or p15 were defective in six different canine mammary tumor (CMT) cell lines compared to normal thoracic canine fibroblasts. This suggests CKI defects are frequently responsible for neoplastic… CONTINUE READING