Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria.

Abstract

This study was undertaken to develop new dipyridamole (DP) formulations with acidic microenvironmental pH-modifiers for improving dissolution and absorption under hypochlorhydric conditions. Dipyridamole granules (DPG) with ten acidic pH-modifiers were prepared with conventional wet granulation, and their manufacturability, stability and dissolution… (More)
DOI: 10.1016/j.ijpharm.2012.05.040

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Cite this paper

@article{Taniguchi2012NovelFO, title={Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria.}, author={Chika Taniguchi and Ryo Inoue and Yohei Kawabata and Kazuhiro Yamashita and Koichi Wada and Yukinori Yamauchi and Shizuo Yamada and Satomi Onoue}, journal={International journal of pharmaceutics}, year={2012}, volume={434 1-2}, pages={148-54} }