Novel form of drug-dependence—on adenosine in guinea pig ileum

There is evidence that dependence on opiates occurs in neurones bearing their specific receptors, whose activation inhibits the neurone1. Thus, incubation of guinea pig ileum with an opiate induces in the final cholinergic motoneurone of the myenteric plexus a dependence that closely resembles in basic characteristics opiate dependence in whole animals2–6… CONTINUE READING